Development, Validation and Application of a Targeted LC-MS Method for Quantification of Microcystins and Nodularin: Towards a Better Characterization of Drinking Water

Cyanotoxins can be produced in surface waters by cyanobacterial blooms, mostly during summer and early autumn. Intoxications would result from consumption of water contaminated with the potent hepatotoxins, microcystins nodularin. Therefore, WHO has set a guideline value for drinking quality concerning one congener microcystin. Consequently, design validated, public reference method to detect quantify hepatotoxins is necessary. During this study, was developed cyanotoxins (eight microcystin congeners nodularin) using liquid chromatography coupled tandem mass spectrometry. Additionally, bottled tap samples were tested presence cyanotoxins. No detected any collected samples. However, controls results proficiency test show validity method.